Opportunity Information: Apply for RFA CA 21 018
The grant opportunity titled "Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional)" (Funding Opportunity Number RFA-CA-21-018) is a National Cancer Institute (NCI) funding announcement designed specifically for teams that already hold an active NCI U01 cooperative agreement. Rather than funding an entirely new project, this announcement supports revision applications (previously referred to as competing revisions) that expand the scope of an existing, currently funded U01 study. The main goal is to accelerate the real-world use of proven cancer informatics technologies by helping active research projects incorporate methods, tools, or resources that were developed through the NCI Informatics Technology for Cancer Research (ITCR) Program, whether that ITCR support was current or in the past.
At its core, the FOA is about adoption and integration. NCI is encouraging researchers to take informatics innovations that already exist within the ITCR ecosystem and plug them into ongoing cancer research efforts where they can have immediate impact. This might mean adapting an ITCR-developed software tool so it works with the data types or workflows of the parent U01 project, integrating an informatics pipeline into an existing study infrastructure, or extending the study aims so that the informatics technology can be evaluated, improved, and used by the relevant research community. The emphasis is not just on using technology for technology's sake, but on meaningfully enhancing cancer research capabilities and speeding scientific discovery through better data handling, analysis, sharing, and collaboration.
A key feature of the opportunity is its focus on collaboration and cross-disciplinary work. NCI frames these awards as a way to spur new collaborations between the teams running the parent U01 projects and the developers or communities behind ITCR-supported tools. The intent is to create incentives for research groups to adopt and adapt high-value informatics resources instead of reinventing them, and to ensure that these technologies become more widely used, better integrated, and more robust in real research settings. Because the funding mechanism is a U01 cooperative agreement, applicants should also expect substantial NIH/NCI involvement in project oversight and coordination compared with typical investigator-initiated grants.
Administratively, this is a discretionary federal funding opportunity offered by the Department of Health and Human Services through the National Institutes of Health. It falls under an education and health activity category and is associated with multiple CFDA numbers (93.393, 93.394, 93.395, 93.396, 93.399), reflecting NCI's broader cancer research funding authorities. The announcement lists a wide range of eligible applicants, including federal-recognized tribal governments and tribal organizations, state and local governments, public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), public housing authorities/Indian housing authorities, for-profit organizations (other than small businesses), and small businesses, plus other entities as clarified in the full eligibility text. In practice, the central eligibility constraint is implied by the purpose statement: the applicant must be in a position to submit a revision to an existing, currently funded NCI U01 project that can be expanded using ITCR-supported informatics technology.
Funding is relatively modest and targeted, with an award ceiling of $100,000 and an expectation of about 4 awards. The FOA was created on December 2, 2020, with an original closing date of November 17, 2021. The "Clinical Trials Optional" designation indicates that the proposed revision work may include clinical trial-related components if appropriate, but a clinical trial is not required. Overall, the opportunity is best understood as a small, strategic infusion of funds intended to move ITCR-derived informatics advances into broader, practical use within active NCI-supported cancer research projects, strengthening interoperability, accelerating research workflows, and building interdisciplinary bridges that help innovations spread.Apply for RFA CA 21 018
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on Dec 02, 2020.
- Applicants must submit their applications by Nov 17, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Applicants who have applied for this opportunity (RFA CA 21 018) also looked into and applied for these:
| Funding Opportunity |
|---|
| Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional) Apply for RFA CA 21 013 Funding Number: RFA CA 21 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (R01 Clinical Trials Optional) Apply for RFA CA 21 017 Funding Number: RFA CA 21 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trial Optional) Apply for RFA CA 21 019 Funding Number: RFA CA 21 019 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3 Clinical Trial Optional) Apply for PAR 21 092 Funding Number: PAR 21 092 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Coordination and Dissemination Center (R24 Clinical Trial Optional) Apply for RFA DA 21 029 Funding Number: RFA DA 21 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $575,000 |
| Limited Competition to Convert the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Study Cohort to a Research Resource (R24 - Clinical Trial Not Allowed) Apply for RFA MH 21 170 Funding Number: RFA MH 21 170 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,250,000 |
| Proteogenomic Data Analysis Centers (PGDACs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 024 Funding Number: RFA CA 21 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
| Proteogenomic Translational Research Centers (PTRCs) for Clinical Proteomic Tumor Analysis Consortium (U01 Clinical Trial Not Allowed) Apply for RFA CA 21 025 Funding Number: RFA CA 21 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Proteome Characterization Centers (PCCs) for Clinical Proteomic Tumor Analysis Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 023 Funding Number: RFA CA 21 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| 3D Technologies to Accelerate HTAN Atlas Building Efforts (UH2 Clinical Trial Not Allowed) Apply for RFA CA 21 037 Funding Number: RFA CA 21 037 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Coordinating Center for Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes (ENICTO) in Cancer Survivors Consortium (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 032 Funding Number: RFA CA 21 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $875,000 |
| Network of the National Library of Medicine All of Us Program Center (U24) (Clinical Trial Optional) Apply for RFA LM 21 002 Funding Number: RFA LM 21 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $3,200,000 |
| Cancer Target Discovery and Development (CTD2) (U01 Clinical Trial Not Allowed) Apply for PAR 21 274 Funding Number: PAR 21 274 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Indian Health Service National Indian Health Outreach and Education Apply for HHS 2023 IHS NIHOE 0001 Funding Number: HHS 2023 IHS NIHOE 0001 Agency: Department of Health and Human Services, Indian Health Service Category: Education, Health Funding Amount: $851,311 |
| Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA CA 22 032 Funding Number: RFA CA 22 032 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Radiation Oncology-Biology Integration Network (ROBIN) Centers (U54 Clinical Trial Required) Apply for RFA CA 22 046 Funding Number: RFA CA 22 046 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Consortium on Translational Research in Early Detection of Liver Cancer: Translational Research Centers (U01 Clinical Trial Optional) Apply for RFA CA 22 031 Funding Number: RFA CA 22 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
| American Indians into Medicine Apply for HHS 2024 IHS INMED 0001 Funding Number: HHS 2024 IHS INMED 0001 Agency: Indian Health Service Category: Education, Health Funding Amount: $700,000 |
| American Indians into Nursing Apply for HHS 2024 IHS NU 0001 Funding Number: HHS 2024 IHS NU 0001 Agency: Indian Health Service Category: Education, Health Funding Amount: $400,000 |
| American Indians into Psychology Apply for HHS 2024 IHS INPSY 0001 Funding Number: HHS 2024 IHS INPSY 0001 Agency: Indian Health Service Category: Education, Health Funding Amount: $267,500 |
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