Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed) | RFA HG 27 010

Opportunity Information: Apply for RFA HG 27 010

The National Institutes of Health (NIH) is offering a cooperative agreement funding opportunity titled "Computational Modeling and Analysis of the Impact of Genomic Variation on Function" under the UM1 mechanism, with clinical trials not allowed. The program is designed to support centers that can build, apply, and rigorously test predictive computational models and integrative analysis approaches that clarify how genomic variation affects genome function. In practical terms, NIH is looking for teams that can connect DNA sequence differences (such as variants identified through sequencing studies) to functional consequences across biological systems, using modern computational methods, statistical modeling, and multi-omic data integration.

Awardees will become part of the Impact of Genomic Variation on Function (IGVF) Consortium, meaning the work is intentionally organized as a coordinated, multi-site effort rather than a set of isolated projects. As consortium members, funded centers are expected to collaborate closely with other IGVF components. This includes helping shape and optimize experimental design across the broader consortium, providing analytical expertise and support that others can rely on, and participating in shared, consortium-wide analysis plans aimed at meeting IGVF goals. A strong emphasis is placed on making consortium resources broadly accessible, so successful applicants should be prepared to contribute tools, models, workflows, and outputs in ways that can be used by many different scientific audiences, not just the originating lab or institution.

This opportunity is released as RFA-HG-27-010 and uses the cooperative agreement funding instrument, which typically involves substantial NIH programmatic involvement and coordination compared to a standard research project grant. The activity category is health, and the CFDA number listed is 93.172. The program anticipates making around five awards, with an award ceiling of $800,000 (as stated in the source information). The original application closing date is December 14, 2026, indicating a relatively long runway for planning complex center-scale proposals.

Eligibility is broad and includes many organization types: federal recognized tribal governments and tribal organizations, state and local governments, public and private institutions of higher education, nonprofits with or without 501(c)(3) status, public housing authorities/Indian housing authorities, for-profit organizations (including those other than small businesses), small businesses, and other eligible entities. Importantly, non-U.S. entities are eligible to apply, and foreign components of U.S. organizations are allowed as defined by NIH policy. That said, applicants need to pay close attention to NIH rules on international collaborations: NIH will not issue awards that include foreign subawards or subcontracts under this NOFO. Any application proposing foreign subawards/subcontracts will be considered noncompliant and will not be reviewed for funding. This restriction does not prevent unfunded international collaborations, foreign components (as permitted), payments to foreign consultants, or purchasing specialized equipment or supplies from foreign vendors, but it does prohibit funded foreign subaward/subcontract arrangements unless the application is submitted to a NOFO specifically intended for funded international collaborations.

Overall, the opportunity targets research groups capable of leading sophisticated computational and analytical efforts at consortium scale, with a clear expectation of teamwork, shared strategy, and user-oriented dissemination of methods and resources. The goal is to advance reliable, predictive understanding of how genetic variation influences function, while building a coordinated infrastructure of models, analyses, and accessible outputs that can accelerate interpretation of genomic variation across biomedical research.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
• This funding opportunity was created on 2026-10-09.
• Applicants must submit their applications by 2026-12-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $800,000.00 in funding.
• The number of recipients for this funding is limited to 5 candidate(s).
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA HG 27 010

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