Studies in Neonatal and Pediatric Resuscitation (R01 Clinical Trial Optional) | PA 18 485

Opportunity Information: Apply for PA 18 485

The Studies in Neonatal and Pediatric Resuscitation (R01 Clinical Trial Optional) funding opportunity (NIH, PA-18-485; CFDA 93.865) supports research aimed at improving how newborns and children are resuscitated and cared for immediately after life-threatening events. The central goal is to generate stronger scientific evidence that can be translated into real-world, evidence-based resuscitation guidelines and bedside practices, with an emphasis on improving both short-term survival and long-term health outcomes. In practical terms, NIH is looking for projects that help clinicians understand what works best during resuscitation, why it works, and how early decisions and interventions affect outcomes months or years later.

The scientific scope is intentionally broad and covers many points along the perinatal and pediatric resuscitation continuum. Example areas specifically highlighted include fetal-to-newborn transitional physiology, especially cardiovascular and pulmonary changes during the critical minutes around birth; optimizing the individual steps and sequencing of resuscitation (for example, ventilation strategies, oxygen use, chest compressions, medications, and monitoring approaches); and understanding how management of the third stage of labor (the period after delivery of the baby until delivery of the placenta) may influence fetal or newborn status and resuscitation needs. The FOA also invites studies focused on resuscitating children with congenital malformations or other complex conditions, as well as research that links resuscitation approaches to longer-term neurodevelopmental, cardiopulmonary, and overall functional outcomes. Post-resuscitation care is another major theme, recognizing that what happens after return of spontaneous circulation or stabilization in the delivery room or emergency setting can strongly shape recovery trajectories.

The announcement is flexible about study designs, reflecting the reality that resuscitation research often requires multiple complementary approaches. Applicants may propose epidemiologic work (such as incidence, risk factors, variation in care, or outcomes across populations), animal studies using fetal-neonatal models to examine mechanisms and physiology, and computer-based or other technology-driven simulation approaches that model resuscitation scenarios or test decision-support concepts. Clinical observational studies are explicitly welcomed, as are analyses of existing national or regional datasets, which can be particularly valuable for studying rare events, practice variability, or longer-term outcomes at scale. The FOA also allows opportunistic studies (for example, leveraging clinical circumstances where data collection can occur without disrupting urgent care) and prospective randomized controlled trials. Because the mechanism is R01 and clinical trials are optional, applicants can propose either non-trial research or full interventional trials, as long as the question and methods are rigorous and appropriate for the resuscitation setting.

Eligibility is expansive across many U.S.-based organization types, reflecting an interest in broad participation and the ability to study diverse populations and care environments. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and tribal organizations that are not federally recognized. The FOA also permits applications from public housing authorities/Indian housing authorities, nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education), for-profit organizations (other than small businesses), and small businesses, as well as other eligible entities. It also calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.

At the same time, there are clear restrictions related to foreign involvement. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply. Non-domestic components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed under this announcement. In other words, the work and organizational structure must remain within eligible U.S.-based parameters.

Administratively, this is an NIH discretionary grant opportunity using the R01 research project grant mechanism. The source record lists an original closing date of 2021-01-07, indicating that applicants would need to confirm current submission windows and active receipt dates through NIH systems if the opportunity has been reissued or remains available under standard NIH cycles. The funding record does not specify an award ceiling or expected number of awards in the provided text, which is not unusual for NIH program announcements, where budgets are typically determined by project scope, NIH policies, and institute-specific considerations.

Overall, the FOA is designed to push the field toward clearer, data-driven resuscitation practices for newborns and children. It encourages applicants to tackle both foundational physiology questions and highly practical clinical questions, using whatever mix of methods is best suited to the realities of resuscitation research. The expected payoff is stronger evidence that can reduce uncertainty during high-stakes events and improve outcomes not only in the delivery room or emergency department, but across the child s longer-term development and health.

• The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Studies in Neonatal and Pediatric Resuscitation (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
• This funding opportunity was created on 2017-12-11.
• Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 18 485

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: