Opportunity Information: Apply for 22 600
The Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences is a collaborative grant program run by the National Science Foundation (NSF), through its Division of Mathematical Sciences (DMS) in the Directorate for Mathematical and Physical Sciences (MPS), together with the National Institutes of Health (NIH), through the National Institute of General Medical Sciences (NIGMS). The central aim is to fund fundamental advances in mathematics and statistics that are motivated by, and ultimately help solve, important problems in the biological and biomedical sciences. In practical terms, the opportunity is meant for research that genuinely sits at the crossroads of the two areas, where mathematical or statistical innovation is not just a supporting tool but a key driver for new biological insight.
A major emphasis of the program is strengthening research at the mathematical-life science interface by encouraging cross-disciplinary work. It is explicitly designed to both spark new collaborations (for example, mathematicians teaming up with biologists, biomedical researchers, or data scientists for the first time) and to accelerate creative, higher-risk or forward-looking directions within teams that already have an established collaborative track record. The program’s framing signals that proposals should do more than apply existing methods to biological datasets; instead, they should develop or substantially extend mathematical, statistical, or computational theory in ways that are necessary to address biological and biomedical questions.
Applicants can submit proposals under one of two tracks that are differentiated mainly by project scale and duration. Track 1 supports smaller projects with a total budget up to $600,000 over a 3-year award period, which is well-suited for focused collaborations, pilot efforts, or tightly scoped research plans that can deliver foundational mathematical/statistical contributions and clear biological relevance within that timeframe. Track 2 supports larger projects with total budgets up to $1,200,000 over 3 to 4 years, intended for more expansive programs of work, potentially involving larger teams, more ambitious theory development, or broader integration across mathematical and biological components. The maximum award ceiling listed for the opportunity is $1,200,000, aligning with the Track 2 cap.
From an administrative standpoint, this is a discretionary, grant-based funding opportunity in the category of science and technology and other research and development. It is listed under CFDA numbers 47.049 and 93.859, reflecting the NSF and NIH participation. Eligibility is described as unrestricted, meaning it is broadly open to a wide range of applicant organization types, with the caveat that applicants should still check any additional eligibility clarifications in the full solicitation text. The opportunity (Funding Opportunity Number 22-600) was created on June 1, 2022, with an original closing date of September 19, 2022, and it anticipated making around 25 awards.
Overall, the grant is best understood as an investment in the kind of research where new mathematical or statistical ideas are developed because biology demands them, and where those ideas, in turn, enable deeper understanding of biological or biomedical systems. The two-track structure gives teams a choice between a more compact 3-year effort and a larger, longer project, while keeping the program’s core expectation the same: substantive, innovative work that advances mathematics/statistics and directly engages meaningful life science questions.Apply for 22 600
- The National Science Foundation in the science and technology and other research and development sector is offering a public funding opportunity titled "Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 47.049, 93.859.
- This funding opportunity was created on Jun 01, 2022.
- Applicants must submit their applications by Sep 19, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,200,000.00 in funding.
- The number of recipients for this funding is limited to 25 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is the Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences?
It is a collaborative grant program run jointly by the National Science Foundation (NSF) and the National Institutes of Health (NIH). On the NSF side, it is managed through the Division of Mathematical Sciences (DMS) in the Directorate for Mathematical and Physical Sciences (MPS). On the NIH side, it is managed through the National Institute of General Medical Sciences (NIGMS). The program funds research that sits at the intersection of mathematical/statistical sciences and biological/biomedical sciences.
What is the main goal of this funding opportunity?
The central aim is to support fundamental advances in mathematics and statistics that are motivated by important problems in the biological and biomedical sciences, and that ultimately help solve those problems. The expectation is that mathematical or statistical innovation is a key driver of new biological insight, not just a supporting tool.
What kinds of projects are a good fit for this program?
Projects that genuinely operate at the crossroads of the mathematical/statistical sciences and the biological/biomedical sciences. Proposals are expected to develop or substantially extend mathematical, statistical, or computational theory in ways that are necessary to address biological or biomedical questions, rather than simply applying existing methods to biological datasets.
Does the program emphasize interdisciplinary collaboration?
Yes. A major emphasis is strengthening research at the mathematical-life science interface by encouraging cross-disciplinary work. The program is framed to support collaborations between mathematicians, statisticians, computational researchers, and life science or biomedical researchers.
Is this opportunity intended only for established teams, or can new collaborations apply?
It is explicitly designed to do both: spark new collaborations (for example, first-time collaborations between mathematicians and biologists/biomedical researchers/data scientists) and accelerate creative, higher-risk, or forward-looking directions for teams that already have an established collaborative track record.
What are the two proposal tracks and how do they differ?
Applicants may submit under one of two tracks that primarily differ in scale, budget, and duration:
- Track 1: Smaller projects up to a total budget of $600,000 over a 3-year award period.
- Track 2: Larger projects up to a total budget of $1,200,000 over a 3- to 4-year award period.
What is the maximum award amount under this opportunity?
The maximum award ceiling listed is $1,200,000, which aligns with the Track 2 cap.
How long can a project be funded under each track?
Track 1 awards are for 3 years. Track 2 awards are for 3 to 4 years.
What is Track 1 best suited for?
Track 1 is described as well-suited for focused collaborations, pilot efforts, or tightly scoped research plans that can deliver foundational mathematical/statistical contributions and clear biological relevance within a 3-year timeframe.
What is Track 2 best suited for?
Track 2 is intended for more expansive programs of work, potentially involving larger teams, more ambitious theory development, or broader integration across mathematical and biological components, supported over 3 to 4 years.
What does the program mean by "fundamental advances" in mathematics and statistics?
Based on the program framing, it means proposals should develop new or substantially extended mathematical, statistical, or computational theory. The mathematics/statistics should not be incidental; it should be essential to addressing the biological/biomedical question and should advance the mathematical/statistical sciences in its own right.
Is simply applying existing mathematical or statistical methods to biological data sufficient?
The opportunity statement signals that proposals should do more than apply existing methods to biological datasets. Instead, the expectation is development or substantial extension of theory or methods driven by biological/biomedical needs.
What type of funding mechanism is this?
It is a discretionary, grant-based funding opportunity categorized under science and technology and other research and development.
Which agencies are involved in administering or sponsoring the program?
The program is collaborative between NSF and NIH. Specifically, it involves NSF (DMS within MPS) and NIH (NIGMS).
What are the CFDA numbers associated with this opportunity?
The opportunity is listed under CFDA numbers 47.049 and 93.859, reflecting NSF and NIH participation.
What is the Funding Opportunity Number for this program?
The Funding Opportunity Number provided is 22-600.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is broadly open to a wide range of applicant organization types. At the same time, applicants are advised to check for any additional eligibility clarifications in the full solicitation text.
When was this opportunity created and what was the original closing date?
The opportunity was created on June 1, 2022, and the original closing date was September 19, 2022.
Approximately how many awards were anticipated?
The opportunity anticipated making around 25 awards.
What is the overall "best understanding" of what this grant is trying to fund?
It is positioned as an investment in research where biology demands new mathematical or statistical ideas, and those new ideas then enable deeper understanding of biological or biomedical systems. The two-track structure provides options for project size and duration, while keeping the same core expectation: substantive, innovative work that advances mathematics/statistics and directly engages meaningful life science questions.
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