Opportunity Information: Apply for W81XWH 18 BCRP BTA12 2
The DoD Breast Cancer Research Program (BCRP) Breakthrough Award Levels 1 and 2 (Funding Opportunity Number W81XWH-18-BCRP-BTA12-2) is a discretionary Department of Defense funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It supports science and technology research and development aimed at breast cancer, using either a grant or cooperative agreement funding instrument. The overarching purpose is to back research that is genuinely positioned to produce a breakthrough, meaning work that could materially shift how breast cancer is understood, prevented, detected, or treated, rather than delivering only incremental progress.
A central expectation of this award is clear, patient-centered impact. Proposed projects are supposed to have high potential to accelerate progress toward ending breast cancer, with impacts that may be near-term or longer-term. What matters is that the work aims beyond a modest refinement and instead points toward a new approach that could be fundamentally better than current interventions that are already approved or even those still in clinical development. Applicants are also expected to specify who ultimately benefits, meaning they should identify the breast cancer patient populations or at-risk individuals that the research is intended to help, rather than leaving the clinical or public health relevance implied.
The program offers two funding levels in this announcement, and the level chosen is meant to reflect the scope and maturity of the science rather than simply the size of the budget. Funding Level 1 is designed for innovative, high-risk/high-reward ideas at the earliest stages of development. These are projects that might open up entirely new avenues of investigation and are often framed around establishing a proof of concept; importantly, preliminary data are not required at Level 1, which makes it attractive for bold concepts that are not yet well supported by existing results. Funding Level 2 is intended for research that already has preliminary data in hand and is positioned to make meaningful advances toward clinical translation. In other words, Level 2 is for teams that can show early evidence supporting feasibility or biological rationale and are ready to push the work toward outcomes that could plausibly influence future patient care, even though the projects under this announcement cannot themselves be clinical trials. (Applicants looking to conduct a clinical trial are directed to the separate Breakthrough Award Levels 3 and 4 announcement, W81XWH-18-BCRP-BTA34-2.)
Collaboration is explicitly encouraged through a Partnering PI Option. Under this structure, two principal investigators can apply together as an Initiating PI and a Partnering PI, and each PI would receive a separate award while jointly advancing a unified research project. Even though the submission requirements differ between the two PI roles, the intent is that both investigators meaningfully shape the core parts of the application, including the Project Narrative and Statement of Work, and bring clearly distinct contributions. The program welcomes collaborations across similar or very different disciplines, but it expects applicants to explain why the collaboration is necessary and how the combined expertise will tackle the research question better than two separate, loosely connected efforts. The announcement also discourages investigators from serving as a Partnering PI on multiple Breakthrough Award Level 1 or 2 applications unless the projects are clearly addressing different research questions, and it makes clear that a mentor-trainee pairing (such as a mentor and a current postdoctoral fellow or junior investigator) does not fit the intent of the Partnering PI mechanism.
From a project execution standpoint, applicants are expected to assemble a robust research team with appropriate expertise in breast cancer and the relevant technical areas to carry out the proposed work successfully. Research involving human subjects and human anatomical substances is allowed, which can include studies using patient samples or other human-derived materials, but the mechanism does not permit clinical trials under Levels 1 and 2. Finally, the proposed work must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the American public, reflecting the DoD mandate that funded research should connect to the health needs of military communities while also benefiting broader public health.
Administrative details in the source record indicate the opportunity was created July 17, 2018, with an original closing date of November 15, 2018. Eligibility is listed as unrestricted (open to any type of entity), subject to any additional eligibility clarifications contained in the full announcement. The listing also notes an expected number of awards of around 20, and the CFDA number associated with this program area is 12.420.Apply for W81XWH 18 BCRP BTA12 2
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer, Breakthrough Award Levels 1 and 2" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jul 17, 2018.
- Applicants must submit their applications by Nov 15, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 20 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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