Opportunity Information: Apply for PAR 18 752
The National Cancer Institute (NCI) administrative supplement opportunity PAR-18-752 was created under the Cancer Moonshot initiative to speed up progress in cancer research, specifically around why cancers become resistant to treatment or, in some cases, unusually sensitive to certain drugs. It was developed in response to guidance from the Cancer Moonshot Blue Ribbon Panel, which identified major research areas where targeted investment and coordination could quickly move the field forward. Rather than funding entirely new standalone projects, this program provides add-on (supplemental) funds to strengthen and extend existing NCI-funded grants and cooperative agreements through new collaborations connected to a Moonshot-supported network.
At the center of the program is the Drug Resistance and Sensitivity Network (DRSN), a group of centers of excellence funded through U54 cooperative agreements. These DRSN centers are set up to use advanced experimental systems, analytical approaches, and disease models to better understand mechanisms of resistance and exceptional sensitivity to anticancer agents. The network also has a practical, translational role: it is intended to help address drug resistance issues that arise during the development of NCI investigational new drug (IND) agents, including agents being developed jointly with pharmaceutical partners and evaluated in NCI-sponsored early-phase clinical trials. In other words, the DRSN is meant to be both discovery-oriented (mechanisms and biology) and pipeline-oriented (supporting therapeutic development decisions).
This supplement FOA is aimed at investigators who already hold an active NCI grant or cooperative agreement and want to add a new, interdisciplinary collaboration with investigators at a DRSN U54 center. A key feature is that these collaborations are intended to connect non-U54 investigators (researchers not funded through the DRSN U54 awards) with DRSN-funded teams, so that existing NCI-funded projects can plug into the DRSN expertise, platforms, and model systems. The work supported must stay within the scientific scope of the parent award (or awards), meaning the supplement is meant to expand or accelerate the funded project rather than redirect it into an unrelated area.
Scientifically, the goal is to generate improved preclinical evaluations and stronger evidence around new findings in cancer drug resistance. The expectation is that supplement-supported studies will sharpen the understanding of resistance or sensitivity in ways that can inform the next steps in therapy development. While the ultimate vision is to enable findings that could later be tested in NCI-sponsored clinical trials, this specific opportunity is labeled “Clinical Trial Not Allowed,” so the funded supplement activities themselves must remain preclinical and not include conducting a clinical trial.
From an administrative standpoint, the award is issued as a grant supplement under a discretionary funding program administered by the U.S. Department of Health and Human Services through the National Institutes of Health. The opportunity listed an award ceiling of $250,000 and anticipated making about two awards. It is associated with CFDA numbers 93.394 and 93.395. The original posting date was April 11, 2018, with an original closing date of June 30, 2018, reflecting that it was a time-bound call for administrative supplements rather than an ongoing multi-year standalone mechanism.
Eligibility is broad and spans many organization types that can hold NIH/NCI awards, including state, county, and city governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; and other entities as described in the NIH eligibility language. In practical terms, the applicant must already have an eligible, active NCI-funded parent award to which the supplement would be attached, and the proposed collaboration must be justified as a scoped extension of that existing project.
Overall, PAR-18-752 is best understood as a Moonshot-driven bridge between the broader NCI-funded research community and the specialized DRSN U54 centers. It uses administrative supplements to rapidly catalyze collaborative, preclinical work on drug resistance and exceptional sensitivity, with the longer-term intent of improving the quality and readiness of discoveries that may eventually support NCI-sponsored clinical testing, without funding clinical trials directly under this supplement mechanism.Apply for PAR 18 752
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Administrative Supplements to NCI Grant and Cooperative Agreement Awards to Support Collaborations with the Drug Resistance and Sensitivity Network (DRSN)(Admin Supp Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
- This funding opportunity was created on Apr 11, 2018.
- Applicants must submit their applications by Jun 30, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| The National Drug Abuse Treatment Clinical Trials Network (UG1 Clinical Trial Optional) Apply for RFA DA 19 008 Funding Number: RFA DA 19 008 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
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| Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R21 Clinical Trials Not Allowed) Apply for RFA CA 19 019 Funding Number: RFA CA 19 019 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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