Opportunity Information: Apply for RFA DK 19 023
The Type 1 Diabetes in Acute Pancreatitis Consortium - Data Coordinating Center (T1DAPC-DCC) funding opportunity (RFA-DK-19-023) is a National Institutes of Health (NIH), Department of Health and Human Services cooperative agreement (U01) aimed at building the central coordinating hub for a new multi-site research consortium studying diabetes that develops during or after acute pancreatitis, with particular attention to type 1 diabetes mellitus (T1D). The overall consortium structure includes one Data Coordinating Center (DCC) funded under this announcement and up to 10 separately funded Clinical Centers (CC) that apply through a companion FOA (RFA-DK-19-022). The clinical trial designation is "optional," but the core planned effort is a prospective, longitudinal observational study that follows individuals who experienced one or more episodes of acute pancreatitis to understand how often diabetes occurs, what forms it takes, how it evolves over time, and what biological mechanisms may be driving it.
The scientific focus is on clarifying the incidence, clinical course, underlying causes, and pathophysiology of diabetes emerging in the context of acute pancreatitis, with emphasis on identifying and characterizing cases that meet criteria for T1D. The consortium is intended to answer questions that are difficult for single institutions to address alone, such as whether certain acute pancreatitis etiologies or clinical patterns are linked to later autoimmune diabetes, how quickly dysglycemia develops after recovery, and how to distinguish T1D from other pancreatitis-associated diabetes phenotypes. A major element is the search for immune and genetic risk factors, along with measurable biomarkers, that could predict who is most likely to develop T1D after pancreatitis. Importantly, the study population is expected to be racially, ethnically, and geographically diverse, and to include people recovering from acute pancreatitis due to multiple identifiable causes, improving the generalizability and clinical usefulness of findings.
The DCC is positioned as the operational backbone of the consortium. Applicants are expected to bring demonstrated experience serving as a data coordinating center for complex clinical research programs, particularly in settings involving heterogeneous patient populations, multi-site recruitment, longitudinal follow-up, and outcomes that require careful phenotyping (such as different diabetes subtypes). In practical terms, the DCC is responsible for overall project coordination and administration across participating sites, development and maintenance of the study data infrastructure, and delivery of high-quality biostatistical support. This typically includes creating standardized case report forms and data dictionaries, building secure data capture and management systems, overseeing data quality assurance and quality control processes, supporting consistent protocol implementation across sites, coordinating communications and reporting, and leading or supporting the analytic plan for incidence estimates, risk modeling, and biomarker evaluation. The DCC also generally plays a central role in harmonizing procedures across CCs so that biospecimens, immune assays, genetic data, and clinical endpoints can be compared reliably and combined for pooled analyses.
From an administrative standpoint, this is a discretionary NIH grant mechanism using a cooperative agreement, which signals that NIH program staff are expected to have substantial involvement in the planning, governance, and execution of the consortium activities compared with a traditional investigator-initiated R01. The opportunity lists a broad range of eligible applicants, including federal recognized tribal governments and tribal organizations, state and local governments, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit entities (other than small businesses), and small businesses, with additional eligibility details referenced in the full announcement. The funding opportunity was created December 9, 2019, with an original closing date of March 13, 2020, and it anticipates a single award for the DCC. The award ceiling is shown as 0 in the provided listing, which typically indicates that applicants must consult the full FOA for budget guidance and allowable costs rather than relying on a fixed maximum in the summary record.
In short, this FOA is designed to stand up a centralized coordinating center that can run the data, operations, and statistical engine for a national consortium investigating how and why T1D and other forms of diabetes can arise during or after acute pancreatitis, and how immune, genetic, and biomarker signals might help predict and classify diabetes risk in a diverse set of patients over time.Apply for RFA DK 19 023
- The Department of Health and Human Services, National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Type 1 Diabetes in Acute Pancreatitis Consortium - Data Coordinating Center (T1DAPC-DCC) (U01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on Dec 09, 2019.
- Applicants must submit their applications by Mar 13, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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