Opportunity Information: Apply for RFA NS 22 036
The NINDS Interdisciplinary Team Science Grant (RM1 Clinical Trial Optional), funding opportunity number RFA-NS-22-036, is a National Institutes of Health discretionary grant designed to back ambitious, high-impact neuroscience research that fits within the mission of the National Institute of Neurological Disorders and Stroke (NINDS). The core idea is to fund a tightly coordinated team effort rather than a set of loosely connected projects. Applications are expected to propose bold, challenging work with the potential to be genuinely transformative, and teams are encouraged to define clear outcomes they expect to achieve over a five-year period.
A defining feature of this program is its emphasis on true interdisciplinary team science. Projects must be led by three or more, and up to six, Program Directors/Principal Investigators (PDs/PIs) who jointly pursue a single shared objective that cannot be accomplished without active collaboration. NINDS is looking for real synergy: integrated planning, managed team interactions, and a unified research strategy where each part depends on and strengthens the others. In practical terms, the proposed work should not look like several investigators each doing their own piece in parallel. Instead, it should read as one cohesive research plan with one overarching focus and one coordinated set of specific aims that require the team to work together throughout the project.
This RM1 opportunity is explicitly positioned as different from the NINDS P01 mechanism. While P01s often include multiple subprojects, this program is built around a single, well-integrated research plan and a single consolidated budget without subprojects. That structure reinforces the expectation that the work is unified and that success depends on the team functioning as a tightly connected unit rather than a collection of semi-independent components.
The announcement is labeled "Clinical Trial Optional," meaning applicants may propose a project that includes a clinical trial if it fits the scientific goals, but a clinical trial is not required. The overall scientific scope is broad, as long as the research falls within NINDS mission areas, which generally cover neurological disorders, stroke, and fundamental neuroscience relevant to those conditions.
Eligibility is wide and includes many types of U.S.-based organizations and government entities. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. The FOA also highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Foreign participation is limited in a specific way. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components are allowed as defined by the NIH Grants Policy Statement, meaning a U.S. applicant may be able to include certain foreign elements in the project when well-justified and consistent with NIH policy.
The FOA falls under the NIH health funding activity category and is associated with CFDA number 93.853. The original closing date listed for this opportunity was May 17, 2023, and the posting indicates it was created on May 18, 2022. The award ceiling and expected number of awards are not specified in the provided source details, so applicants would typically need to refer to the full FOA text or NIH notices for budget guidance and anticipated award volume.Apply for RFA NS 22 036
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NINDS Interdisciplinary Team Science Grant (RM1 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on 2022-05-18.
- Applicants must submit their applications by 2023-05-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): NINDS Interdisciplinary Team Science Grant (RM1 Clinical Trial Optional) - RFA-NS-22-036
What is this funding opportunity?
This opportunity is the NINDS Interdisciplinary Team Science Grant (RM1 Clinical Trial Optional), funding opportunity number RFA-NS-22-036. It is an NIH discretionary grant intended to support ambitious, high-impact neuroscience research aligned with the mission of the National Institute of Neurological Disorders and Stroke (NINDS).
What is the main purpose of the RM1 Interdisciplinary Team Science Grant?
The goal is to fund bold, challenging, potentially transformative neuroscience research through a tightly coordinated interdisciplinary team. The emphasis is on a single shared objective that requires active collaboration and cannot be achieved by individual investigators working independently.
What makes this program "interdisciplinary team science" rather than a collection of related projects?
NINDS is looking for real synergy: integrated planning, managed team interactions, and a unified research strategy where each part depends on and strengthens the others. The application should read as one cohesive research plan with one overarching focus and one coordinated set of specific aims that require the team to work together throughout the project.
How many PDs/PIs are required, and what is the maximum?
Projects must be led by at least three Program Directors/Principal Investigators (PDs/PIs), and no more than six, who jointly pursue the single shared objective.
What does NINDS mean by "a single shared objective"?
It means the proposed team is pursuing one common scientific goal that cannot be accomplished without ongoing collaboration among the PDs/PIs. The work should be interdependent rather than divided into separate, parallel efforts that could stand alone.
How long is the expected project period?
The program materials emphasize defining clear outcomes expected over a five-year period, indicating the team should plan outcomes and milestones across five years.
Is a clinical trial required?
No. The FOA is labeled "Clinical Trial Optional," meaning a clinical trial may be included if it fits the scientific goals, but it is not required.
If we want to include a clinical trial, is that allowed?
Yes. Because the FOA is "Clinical Trial Optional," applicants may propose a project that includes a clinical trial when it is scientifically appropriate for the overall goals of the application.
What scientific areas are in scope for this opportunity?
The scope is broad as long as the research fits within NINDS mission areas, which generally include neurological disorders, stroke, and fundamental neuroscience relevant to those conditions.
How is this RM1 program different from an NINDS P01?
This RM1 opportunity is positioned as different from the NINDS P01 mechanism. Instead of multiple subprojects, the RM1 is built around a single, well-integrated research plan with a single consolidated budget and no subprojects. This structure reinforces the expectation that the project is unified and depends on a tightly connected team effort.
Does the RM1 application use subprojects like a P01?
No. The program description emphasizes a single integrated research plan and a single consolidated budget without subprojects.
What types of organizations are eligible to apply?
Eligibility is broad for U.S.-based organizations and government entities. Eligible applicants include: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses.
Are minority-serving institutions and community-based organizations included as eligible applicants?
Yes. The FOA highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also notes faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Can a foreign (non-U.S.) organization apply as the main applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization for this opportunity.
Can a non-U.S. component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are any foreign activities allowed in the project?
Yes, in a limited way. The FOA indicates that foreign components are allowed as defined by the NIH Grants Policy Statement. That means a U.S. applicant may be able to include certain foreign elements when they are well-justified and consistent with NIH policy.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.853.
When was this funding opportunity posted, and what was the listed closing date?
The posting indicates it was created on May 18, 2022. The original closing date listed was May 17, 2023.
Is the award ceiling provided in the information available here?
No. The award ceiling is not specified in the provided details.
Is the expected number of awards provided in the information available here?
No. The expected number of awards is not specified in the provided details.
Where would applicants typically look for budget guidance or anticipated award volume?
Based on the information provided, applicants would typically need to consult the full FOA text (RFA-NS-22-036) or relevant NIH notices for budget guidance and the anticipated number of awards, since those details are not included in the provided source summary.
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