Opportunity Information: Apply for RFA DK 19 033

The Exploratory Centers for Interdisciplinary Research in Benign Urology (P20, Clinical Trial Optional) funding opportunity (RFA-DK-19-033) is a National Institutes of Health program administered by the Department of Health and Human Services through NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases). Its central purpose is to create or strengthen exploratory research centers focused on benign genitourinary diseases and disorders by deliberately building interdisciplinary teams that can take on innovative questions using integrative approaches. The emphasis is on forming new collaborations and generating early-stage evidence that can open up entirely new research directions or support larger, future studies.

A defining feature of this FOA is its focus on high-risk, high-reward science. Applicants are expected to propose an innovative Research Project that draws on complementary expertise across disciplines rather than staying within traditional urology-only lanes. The program specifically encourages studies involving human subjects or human tissues, and it also supports small pilot and feasibility clinical studies. Because the announcement is labeled "Clinical Trial Optional," applicants may include a clinical trial when it fits the goals of the project, but a clinical trial is not required. The overall intent is to enable exploratory work that might be too preliminary for larger mechanisms, while still being directly relevant to benign urologic conditions.

Team composition requirements are explicit. Each proposed Research Project must include (1) researchers who are new to investigating benign genitourinary diseases or disorders, along with (2) clinical urology expertise. In practice, that means the application should show a genuine integration of new perspectives (for example, investigators from engineering, data science, immunology, neuroscience, microbiology, behavioral science, epidemiology, or other fields not traditionally centered in benign urology) with clinicians who can anchor the work in real-world urologic problems and patient needs. Additional expertise can be added as needed, and the FOA is clearly designed to make those added perspectives a strength rather than an afterthought.

Beyond the single scientific Research Project, each Exploratory Center must include an Administrative Core paired with an Educational Enrichment Program. The Administrative Core is meant to provide leadership, coordination, and management for the center, ensuring the project runs efficiently and that interdisciplinary collaboration is actually operationalized rather than simply described. The Educational Enrichment Program is a required capacity-building component that supports NIDDK's broader goal of expanding the field and growing the pipeline of urologic researchers, particularly in benign urology. While the FOA summary does not spell out every allowable activity in that enrichment program, the intent is to provide structured opportunities such as seminars, workshops, mentorship, or other development activities that strengthen the community of investigators and encourage cross-disciplinary engagement.

This P20 program is also positioned as part of a larger ecosystem of NIDDK-supported urology research infrastructure. The Exploratory Centers are expected to work in partnership with the George M. O'Brien Urology Cooperative Research Centers Program (U54) and with the Multidisciplinary K12 Urologic Research Career Development Programs (KURe and UroEpi). That relationship signals that applicants should think beyond a standalone project and consider how their center will connect into existing collaborative networks and training pipelines, potentially leveraging shared expertise, methods, and career development pathways to accelerate progress in benign urology research.

In terms of basic award information, the opportunity falls under the grant funding instrument type and the "Food and Nutrition, Health" activity category, with CFDA number 93.847. The listed award ceiling is $200,000, and the announcement anticipated making about three awards. Eligibility is broad and includes many types of domestic entities such as state, county, and local governments; public and private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses) and small businesses; tribal governments and tribal organizations; and certain housing authorities, among others, with the FOA noting that additional eligibility details may exist in the full text. The FOA was created on November 12, 2019, and the original closing date was March 31, 2020.

Overall, this opportunity is best understood as a targeted, relatively modestly funded mechanism meant to spark new interdisciplinary collaborations in benign urology, bring new investigators into the field, and produce pilot-level findings (including optional early clinical work) that can mature into larger, more definitive research programs. The required Administrative Core and Educational Enrichment Program reinforce that the goal is not just a single study, but an exploratory center structure that actively builds people, partnerships, and future capacity in benign urologic research.

  • The Department of Health and Human Services, National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Exploratory Centers for Interdisciplinary Research in Benign Urology (P20 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
  • This funding opportunity was created on Nov 12, 2019.
  • Applicants must submit their applications by Mar 31, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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